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Review Open access Sep 2026

Insulin-like growth factor receptor signaling in physiology and disease

The insulin-like growth factor (IGF) signaling pathway plays a pivotal role in regulating a myriad of cellular and physiological processes, including cell proliferation, differentiation, and the maintenance of redox homeostasis. This review provides a comprehensive overview of the IGF/IGF receptor (IGFR) signaling axis...

M. Dilawar, Anoosha Malik, Jun-Guang Liao et al. · 0 citations
Review Aug 2026

Late-stage Functionalization Approaches for Dihydropyrimidinone Scaffolds: Recent Methods and Biological Relevance

3,4-Dihydropyrimidin-2(1H)-ones (DHPMs), synthesized via the classic Biginelli condensation, have emerged as pivotal heterocyclic frameworks with broad medicinal and synthetic relevance. Their intrinsic versatility enables downstream transformations that furnish a diverse spectrum of novel scaffolds. Although multi...

Muhammad Waris Ayub, H. Gondal, A. Akram et al. · 0 citations

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