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Review Open access Oct 2026

Hepatitis E virus genome plasticity: a marker of chronicity and therapy failure?

Hepatitis E virus (HEV) is a globally distributed zoonotic pathogen, spread by contaminated food and blood products, and a leading cause of acute viral hepatitis. Recent data indicate that the HEV genome contains a highly heterogeneous hypervariable region (HVR) that can tolerate extensive genomic rearrangements, espec...

Saskia Janshoff, Leyla Sirkinti, M. Nocke et al. · 0 citations
Open access Sep 2026

Impact of hepatitis E virus host- and virus-derived insertions on the antiviral response in primary human hepatocytes

Background & Aims Despite the global burden of hepatitis E virus (HEV) infection, host-virus interactions underlying HEV pathogenesis and progression to chronicity remain incompletely understood. This study aimed to characterize the host transcriptomic response to infection with HEV variants harboring different host- a...

Sarah Schlienkamp, M. Nocke, Rainer G. Ulrich et al. · 0 citations

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