M. Nordentoft

Study protocol for the Danish High Risk and Resilience Study VIA 19 – from age 15 to age 19: transition from adolescence to early adulthood

Background Longitudinal clinical cohorts following individuals, who are born to parents with severe mental illness, from childhood into adulthood, provide invaluable insight into development of psychopathology, illness course over time and risk and resilience factors. Further, initiatives to prevent mental illness and...

Psychotic and bipolar disorder diagnoses following contact with child and adolescent mental health services-a longitudinal, nationwide register study of 2 million individuals.

BACKGROUND Identification of individuals at elevated risk of schizophrenia spectrum and bipolar disorders is a clinical research priority. Current strategies for psychosis risk identification, however, identify only a small proportion of future cases. Additional high-risk approaches are needed, ideally with higher sens...

Suicidal Ideation and Non-suicidal Self-injury Following Childhood Psychotic Experiences in Adolescents at Familial High Risk of Schizophrenia or Bipolar Disorder-The Danish High Risk and Resilience Study, VIA 15.

Childhood PE, particularly when persistent, mark risk for adolescent SI and NSSI beyond the effects attributable to known risk factors beyond the effects attributable to known risk factors.

Theory of Mind and the Association with Psychotic Experiences in 11-Year-Old Children at Familial High-Risk of Schizophrenia or Bipolar Disorder and Population-Based Controls: The Danish High Risk and Resilience Study, VIA 11.

Children at familial high risk for schizophrenia or bipolar disorder show sex-specific differences in subcortical grey matter volumes

Children at FHR-SZ and FHR-BP exhibited sex-specific differences in subcortical brain volumes before the typical onset of SZ and BP, which may reflect early sex-specific neurodevelopmental correlates of familial risk and highlight the importance of modelling sex-specific effects in developmental neuropsychiatric resear...

Neurocognitive profiles in early childhood in relation to clinical and functional outcomes in middle childhood in offspring at familial high-risk of schizophrenia or bipolar disorder: The Danish High-Risk and Resilience Study.

A significantly impaired neurocognitive profile in early childhood confers risk for detrimental clinical and functional outcomes in middle childhood beyond that which can be attributed to pre-existing clinical and functional states and constitutes a cross-diagnostic, neurodevelopmental risk marker in these FHR-groups.

Mental disorders in adolescents at familial high-risk of schizophrenia or bipolar disorder and population-based controls: An eight-year follow-up study, The Danish High Risk and Resilience Study, VIA 15

Adolescents at FHR-SZ or FHR-BP show elevated risks of a range of mental disorders, psychiatric comorbidity, and lower global functioning from childhood to mid-adolescence, not confined to the disorders for which they carry familial risk.

Persistence of psychotic experiences and clinical outcomes in adolescents at familial high risk of schizophrenia or bipolar disorder: The Danish High Risk and Resilience Study

These findings emphasize PE as important risk markers for mental disorders during mid-adolescence and highlight the importance of monitoring children with PE before age 7 who develop persistent symptoms.