The Alzheimer’s Disease-associated gene CD2AP regulates permeability of endothelial cells and transendothelial migration of immune cells
Variants at the CD2AP locus, which encodes a branched-actin regulator, are associated with late-onset Alzheimer’s disease (AD), and CD2AP-deficient mice show increased blood-brain barrier (BBB) permeability. CD2AP is enriched in endothelial cells, but its function there is poorly understood. In endothelium, branched ac...