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Open access Sep 2026

Impact of Levetiracetam on Hypothalamic-Pituitary-Adrenal Axis Dysregulation, Anxiety-, and Depressive-Like Behaviors in Doxorubicin-Treated Mice

Doxorubicin (DOX) is a highly effective chemotherapeutic agent, yet its clinical utility is frequently compromised by severe neurotoxicity, manifesting as anxiety and depressive-like behaviors. This study investigated the neuroprotective efficacy of the antiepileptic drug levetiracetam (LEV) against DOX-induced affecti...

M. Öz, Fatma Nur Bilgiç · 0 citations
Open access Sep 2026

Attenuation of systemic inflammation-induced behavioral deficits and neuromolecular alterations by N-acetylcysteine in a rodent model

Aims: Systemic inflammation driven by lipopolysaccharide (LPS) induces neurobehavioral deficits, hypothalamic-pituitary-adrenal (HPA) axis dysregulation, and neurodegeneration-related alterations. N-acetylcysteine (NAC) is a potent antioxidant with emerging anti-inflammatory properties. This study investigated whether...

M. Öz, D. A. Aslanlar, Hüseyin Erdal et al. · 0 citations

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