Review
Open access
Aug 2026
Iron regulation by Sirtuins 1 & 2 and their therapeutic modulation by Sirtinol
This review focuses on the role of SIRTs 1 & 2 as tumor promoters, providing a rationale for developing inhibitors like sirtinol for these enzymes, and examines sirtinol’s anti-tumor properties in relation to its ability to function as a tridentate iron chelator.
Koffi Amegble, Lu-Jia Liu, To-Ni Q. Duan et al.
· Frontiers in Pharmacology · 0 citations