ABSTRACT Background Research suggests that multiple genetically influenced pathways of risk impact alcohol use disorder (AUD), including externalizing (disinhibition, behavioral undercontrol), internalizing (negative affect, depression), and alcohol‐specific (physiological response to alcohol) factors. This study exami...
G. Dash, F. Aliev, S. Kuo et al.· Alcohol, clinical & experime...· 0 citations
PGS demonstrated clinically meaningful risk prediction for substance use disorders in EA and LA, supporting the feasibility of future clinical implementation for population-level screening and underscoring the urgent need for more genetic studies in that population.
Dong-Bing Lai, Michael Zhang, Tae-Hwi Schwantes-An et al.· medRxiv· 0 citations
Having a spouse with higher PGSPAU was associated with higher AUDcrit and the social genetic effect of spousal PGSPAU was stronger among male target individuals, highlighting the potential importance of social genetic effects for understanding the pathways from genotype to alcohol use disorder.
S. Kuo, V. McCutcheon, F. Aliev et al.· Alcohol, clinical & experime...· 0 citations
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