M. R. Afnani

Melioidosis in Asia: Hidden burden, epidemiological distribution, vaccine and therapeutic prospects, and public health priorities.

An integrated One Health framework that links human, animal, and environmental health may support more effective surveillance, prevention, and control of melioidosis across Asia.

In Silico Prediction and Structural Mapping of Candidate Linear B-Cell Epitopes in Andes Virus Glycoprotein

In Silico Prediction and Structural Mapping of Linear B-Cell Epitopes in Andes Virus Glycoprotein as Potential Vaccine Candidates

Andes virus (ANDV), a pathogenic orthohantavirus associated with hantavirus cardiopulmonary syndrome, remains a public health concern because of its severe clinical outcomes and the absence of broadly approved vaccines for human use. The viral glycoprotein is a relevant antigenic target because of its surface localizat...

Nipah virus vaccine development: current platforms, preclinical evidence, and clinical translation

Overall, continued advances in translational vaccinology, computational vaccine design, and global preparedness may accelerate the development of NiV vaccines.

In silico screening of potential anti-inflammatory compounds from Sulawesi-endemic Begonia medicinalis

Computational findings suggest that B. medicinalis contains diverse bioactive compounds with potential anti-inflammatory properties, and stigmasterol emerged as the most promising lead candidate against the predicted anti-inflammatory targets.

Expression-Guided Immunoinformatics Design of a Recombinant Multi-Epitope Vaccine Candidate for Triple-Negative Breast Cancer Incorporating a MyD88-Derived Immunomodulatory Domain

Triple-negative breast cancer (TNBC) remains a major therapeutic challenge because of its aggressive behavior, molecular heterogeneity, and limited subtype-specific targets. This study used an integrated immunoinformatics workflow to design a recombinant tumor-associated antigen-derived multi-epitope vaccine based on M...

In silico identification of organosulfur compounds from Allium ascalonicum L. as potential inhibitors of influenza A (H5N1): integrated DFT, docking, and molecular dynamics analysis

It is suggested that shallot-derived organosulfur compounds, especially γ-glutamyl-S-propenylcysteine, exhibit potential for interaction with H5N1 viral targets and may warrant further investigation as antiviral candidates.