Author

M. R. Costa

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Open access Oct 2026

Microglial deficiency of Alzheimer’s genetic risk factor Bin1 elicits enhanced cortical inflammatory response

Bridging Integrator 1 ( BIN1 ) has been identified as the second most important risk locus for developing late-onset Alzheimer’s Disease (AD), after APOE . BIN1 is an adaptor protein implicated in cell membrane dynamics and neuronal BIN1 has been linked to cellular transport mechanisms’ defects, synaptic dysfun...

Maria G. Margariti, Irini Thanou, E. Papadimitriou et al. · Cellular and Molecular Life... · 0 citations

Open access Aug 2026

PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal cultures

It is demonstrated that downregulation of PLCG2, primarily in neurons, impairs synaptic function and elevates amyloid-β levels and Tau protein phosphorylation in neurons.

Audrey Coulon, F. Rabiller, M. Takalo et al. · Nature Genetics · 0 citations

Review Aug 2026

Targeting TDP-43 in sporadic amyotrophic lateral sclerosis

Key biological mechanisms underlying TDP-43 pathology, emerging therapeutic strategies, and evolving approaches to clinical trial design and biomarker development are examined.

C. Estévez-Fraga, R. Álvarez-Velasco, T. Afroz et al. · Journal of Neurology · 1 citation