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Sep 2026

In Vitro Evidences for Renal-Protective Properties of Phloretin in Nephrotoxicity Induced by Bisphenol-A via Mediation of VCAM-1/ICAM-1 Genes Expression

Background: Oxidative stress is a major contributor to kidney dysfunction. Phloretin, a dietary flavonoid, exhibits antioxidant and anti-inflammatory activity. This study evaluated the protective effects of Phloretin against Bisphenol-A (BPA)-induced oxidative stress in human renal tubular epithelial (HK-2) cells. Met...

M. Radan, Kousar Mirhashemi, Fereshte Nejaddehbashi et al. · 0 citations
Open access Aug 2026

Potential Involvement of Redox and Inflammatory Signalling in the Antihyperglycemic and Antioxidant Effects of Harmaline in Male Mice With Type 2 Diabetes

ABSTRACT Introduction Type 2 diabetes mellitus (T2DM) is strongly associated with oxidative stress and inflammation. Harmaline (HAR), an alkaloid with antioxidant and anti‐inflammatory properties, has been suggested to possess antidiabetic potential. This study investigated the effects of HAR in experimental T2DM and i...

Farima Malekinia, Akram Ahangarpour, Khojasteh Hoseinynejad et al. · 0 citations

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