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M. Räschle

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Open access Oct 2026

A selectivity filter in Tim17 mediates intramitochondrial protein sorting

Mitochondria import hundreds of proteins into the matrix and the inner membrane (IM). The translocase of the IM of mitochondria (TIM23 complex) sorts these proteins using topogenic signals in their structure and directs them into the matrix or inserts them into the IM. How these signals are deciphered is unknown. Her...

Annika Egeler, Sanjoy Paul, Rosario Valenti et al. · 0 citations
Open access Aug 2026

ω‐Hydroxyacid Dehydrogenases From Clostridium viride: Iron‐Containing Biocatalysts With Biotechnological Potential

ω‐Hydroxy and oxo acids are versatile platform chemicals, accessible via enzymes of the iron‐containing alcohol dehydrogenase (FeADH) superfamily. Compared with well‐characterized zinc‐dependent ADHs, FeADHs producing such compounds remain poorly defined regarding assignment to genetic locus, biochemical and biophysica...

T. Begic, Julia Hill, J. L. Stitzel et al. · 0 citations

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