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Review Open access Sep 2026

Development and Evaluation of Physiologically Based Pharmacokinetic (PBPK) Models of Metoclopramide Across the Lifespan: Translation from Adults to Infants

Background: Physiologically based pharmacokinetic (PBPK) modeling is an established approach used in recent years for estimating drug disposition in challenging clinical scenarios where in vivo studies are difficult to perform. Metoclopramide is a benzamide derivative, widely indicated for its antiemetic and prokinetic...

Iqra Shahzad, Ammara Zamir, M. Rasool et al. · 0 citations
Review Oct 2026

A systematic review of the clinical pharmacokinetics of fluconazole in healthy and diseased populations.

INTRODUCTION Fluconazole is a triazole antifungal agent commonly used to treat both systemic and superficial fungal infections. This comprehensive review aims to collate all published pharmacokinetic (PK) data on fluconazole in healthy and diseased subjects. METHODS A systematic search of Google Scholar, PubMed, and...

Tahira Saleem, Khadija Ameen, M. Rasool et al. · 0 citations
Review Aug 2026

Exploring the Clinical Pharmacokinetics of Sitagliptin in Healthy and Diseased Populations: A Systematic Critical Review.

The available PK data on sitagliptin from published studies in healthy and diseased subjects are summarized and may be useful for developing physiologically based PK models and may provide additional information to support clinicians in optimizing sitagliptin dosing in patient populations.

Tahira Saleem, M. Rasool, Hamid Saeed et al. · 0 citations

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