The HIF-1α–Mitochondria Axis in Alzheimer's Disease: Therapeutic Potential of Roxadustat in Restoring Neuronal Bioenergetics and Cognitive Function
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-β (Aβ) plaques, tau pathology, mitochondrial dysfunction, oxidative stress, neuroinflammation, and cerebral hypoperfusion. Emerging evidence suggests that dysregulation of the hypoxia-inducible factor-1 alpha (HIF-1α)-mitochon...