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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

M. Rosenkilde

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Open access Aug 2026

Targeting the Oxysterol Receptor GPR183 to Mitigate Fibrogenesis in Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal lung disease with a median survival of 3-5 years after diagnosis. Current antifibrotic therapies slow disease progression, but do not halt or reverse fibrosis, underscoring the need for new therapies. We identified a dysregulated oxysterol-GPR183...

M. Ngo, C. X. Foo, Ziying Hong et al. · 0 citations
Open access Jul 2026

Development of Potent G Protein Pathway-Biased GPR183 Agonists

The detailed structure-activity investigations and optimizations led to the identification of full agonists for GPR183 with complete bias for Gαi protein signaling and low nanomolar potency, including 63 (TUG-2604) with potency and efficacy similar to 7α,25-OHC.

Kaustubh R. Bhuskute, Asmita Manandhar, V. M. S. Kjær et al. · 0 citations

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