Open access
Sep 2026
Toxicity of MAPT 4R RNA Contributes to Motor Neuron Degeneration in ALS
MAPT (Tau) dysregulation is implicated in several neurodegenerative diseases, but its contribution to amyotrophic lateral sclerosis (ALS) is poorly understood. Here we show that mRNA isoforms encoding 4-repeat (4R) Tau are upregulated and cytoplasmically enriched in iPSC-derived motor neurons (MNs) from VCP-mutant and...
H. Crerar, Michele Stasi, Koustav Pal et al.
· bioRxiv · 0 citations