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M. Saito

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Open access Oct 2026

T1R2/T1R3 Identified as the Aβ Receptor: A New Mechanism Linking Aβ42/40 Ratio to Neuronal Hyperexcitability in Alzheimer’s Disease

Early neuronal hyperexcitability is a hallmark of Alzheimer’s disease (AD) and correlates with cognitive decline. A key diagnostic indicator is the reduction in soluble Aβ42/40 ratio - from ∼10% in cognitively normal individuals to ∼5% in AD - which reliably predicts progression to dementia. Although widely used as a b...

M. Saito, M. Saito · 0 citations

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