T1R2/T1R3 Identified as the Aβ Receptor: A New Mechanism Linking Aβ42/40 Ratio to Neuronal Hyperexcitability in Alzheimer’s Disease
Early neuronal hyperexcitability is a hallmark of Alzheimer’s disease (AD) and correlates with cognitive decline. A key diagnostic indicator is the reduction in soluble Aβ42/40 ratio - from ∼10% in cognitively normal individuals to ∼5% in AD - which reliably predicts progression to dementia. Although widely used as a b...