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Open access Aug 2026

Lassa fever and Argentine hemorrhagic fever treatment in guinea pigs using broad-spectrum cap-dependent endonuclease inhibitors

ABSTRACT The class Bunyaviricetes encompasses several highly pathogenic viruses that cause lethal hemorrhagic fevers. Due to their limited prevention and treatment options and high pathogenicity, these viruses require handling in biosafety level-4 facilities. Within the bunyaviruses, arenaviruses are particularly notab...

Junki Maruyama, Satoshi Taniguchi, Takeshi Saito et al. · 0 citations
Open access Aug 2026

Interleukin-34 Promotes Activation of Disease-associated Microglia-like Cells and Attenuates Disease Progression in West Nile Virus Infection

It is shown that interleukin-34 promotes microglial responses resembling disease-associated microglia (DAM) and is associated with enhanced protection against WNV infection in cell culture and mouse models and provides new insights into the role of specific microglial states in viral encephalitis.

Passawat Thammahakin, Keisuke Maezono, T. Dương et al. · 0 citations

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