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M. Sassano

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Sep 2026

Glucose hypometabolism gates tau-dependent necroptosis.

Tau pathology closely tracks neuronal loss in Alzheimer's disease, but how phosphorylated tau becomes lethal has remained unclear. Chen et al. identify a dual-hit mechanism: glucose hypometabolism removes a protective A20-mediated brake on necroptosis while phosphorylated tau scaffolds RIPK1 activation, driving tau-ass...

M. Sassano, B. de Strooper · 0 citations

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