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Open access Sep 2026

Design, Synthesis, and Evaluation of New 1,4‐Naphthoquinone‐1,2,3‐triazoles as Antimalarial Agents

A new series of compounds was evaluated as prospective in vitro antimalarial agents against the chloroquine‐sensitive 3D7 and chloroquine‐resistant K1 strains of Plasmodium falciparum, and the compound bearing a 4‐chloroaryl moiety was the most active against P. falciparum.

Lina Rezainia, M. Sayahi, Eisa Kaveh Vernousfaderani et al. · 0 citations
Open access Aug 2026

Novel diazene-tri(phenoxy-1,2,3-triazole-acetamide) derivatives as potent α-glucosidase inhibitors: synthesis, biological evaluation, and in silico studies

α-Glucosidase is a key therapeutic target for treating type 2 diabetes mellitus. A new series of novel diazene-tri(phenoxy-1,2,3-triazole-acetamide) derivatives 9a–p was designed by hybridizing previously reported potent α-glucosidase inhibitors. The target compounds were successfully synthesized and structurally chara...

Shahab Kermaninia, M. Sayahi, Mohammad Halimi et al. · 0 citations

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