Review
Open access
Sep 2026
Biomarker-Driven Strategies for Stromal Reprogramming in Pancreatic Ductal Adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) remains highly lethal, partly because its dense, heterogeneous stroma restricts drug delivery, promotes immune exclusion, and supports therapeutic resistance. Stromal targeting has, therefore, evolved from broad depletion towards biomarker-guided reprogramming and normalization s...
M. De Luca, Francesco Balestra, Giorgia Panzetta et al.
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