Aug 2026
When lactate speaks: Rewiring astrocyte-neuron metabolism in Alzheimer's disease.
Metabolic dysfunction is a defining but poorly understood feature of Alzheimer's disease. Du et al. show that a brain-penetrant GLP-1 receptor agonist rewires astrocyte-neuron metabolic coupling through lactate-driven histone lactylation, linking astrocytic glycolysis to neuronal lipid homeostasis and positioning metabolite signaling as a therapeutic axis in neurodegeneration.
Jessica Furtado, M. Schneeberger
· Cell Metabolism · 0 citations