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Open access Oct 2026

Structural optimization of novel 1,3,4-oxadiazole-based antibacterial compounds for improved stability.

A 1,3,4-oxadiazole-based compound named 1771 and its derivatives have been reported to exhibit antibacterial activity against Gram-positive bacteria, with activity extending to Gram-negative pathogens upon disruption of the outer membrane permeability barrier and/or efflux pump systems. However, the precise mode of act...

Brandon Marshall, Edward J. A. Douglas, Kyle D. Perrins et al. · 0 citations
Review Open access Sep 2026

Triphosphate and diphosphate nucleoside prodrugs: broadening the therapeutic potential of nucleoside-based treatments

Multiple prodrug strategies have been developed to deliver nucleoside monophosphates (NMPs) and thereby overcome the initial kinase-mediated intracellular phosphorylation of nucleoside analogues (NAs), a major bottleneck in their activation. However, some NAs are limited by a second and/or third slow and inefficient ph...

M. Serpi, Camille Tisnerat, Danielle Krysa et al. · 0 citations

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