M. Shahsavani

Mechanistic insights into the inhibition of insulin amyloidogenesis and associated toxicity by the p.M14L variant of exenatide.

Insulin fibrillation and the subsequent formation of toxic amyloid aggregates are significant challenges in therapeutic development and are associated with cellular proteotoxicity. In this research, we explored how the p.M14L exenatide variant affects the formation of insulin amyloid fibrils. Applying a combination of...