M. Shrubsole

Consumption of Processed Meat and Unprocessed Red Meat and Risk of Bladder Cancer: A Pooled Analysis of 30 Cohort Studies

Background: Processed meat and unprocessed red meat are considered carcinogenic and ‘probably carcinogenic’ to humans, respectively, but findings for bladder cancer remain inconsistent. Objectives: We assessed associations between processed meat and unprocessed red meat intake and bladder cancer risk using data from th...

Discovery and Validation of Gut Microbiome Features Associated with Dietary Patterns in U.S. Black/African and Hispanic/Latino Populations

Importance of faecal sample collection in prospective cohort studies to evaluate the effect of the gut microbiome on cancer development.

The gut microbiome has been linked to cancer in many cross-sectional studies. These studies compared individuals with and without cancer, but they do not establish causation. Prospective cohort studies, with faecal samples collected before a cancer diagnosis, will be instrumental in assessing the role of the gut microb...

Per- and polyfluoroalkyl substances levels other than PFOS, PFOA, or PFHxS and liver cancer risk: a nested case-control analysis.

Perfluoroheptanoic acid (PFHpA) was positively associated with liver cancer risk and no associations were observed for other PFAS, and continued use of short-chain PFAS in consumer products is warranted.

Prioritizing clinical utility to use allostatic load as a biomarker of the consequences of stress.

Robust associations were observed between depression, as a proxy measure of stress, with high allostatic load, supporting its validity as a clinically actionable biomarker of physiological and psychological dysregulation within an understudied population.

Adverse childhood experiences and adult stress eating: A secondary analysis of the Southern Community Cohort Study

The finding that ACEs are associated with adult stress eating across populations, even beyond the impact of depression and other mental-emotional well-being factors, means research is needed to explore whether trauma intervention strategies can mitigate adult stress eating behavior and related poor health outcomes.

Identifying clinical and lifestyle factor mediators of the association between socioeconomic status and colorectal cancer mortality

Differences in early detection and surgical resection are the strongest mediators of the association between income and mortality, and SES-targeted health policies and patient navigation will improve CRC outcomes.