Author

M. Southey

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Open access Sep 2026

Circulating Inflammatory Markers and Mammographic Density Phenotypes: a Mendelian Randomization Analysis

Observational studies have identified associations between circulating inflammatory markers (CIMs) and mammographic density (MD) phenotypes, but whether these associations reflect causal effects remains unclear. We utilized two-sample Mendelian randomization (MR) to assess relationships between 60 CIMs and MD phenotype...

A. H. Suger, T. A. Harrison, C. Haas et al. · medRxiv · 0 citations

Open access Aug 2026

Integration of lipidomic and polygenic risk scores within contemporary clinical cardiovascular risk assessment pathways: a multi-cohort development and validation study

Summary Background Guideline-recommended clinical risk scores such as AusCVDRisk underestimate cardiovascular disease (CVD) risk in a substantial proportion of individuals who later experience events, with up to 65% initially classified as low or intermediate risk. This limitation is most consequential in the intermedi...

Aleksandar Dakic, Jing-Qin Wu, Tingting Wang et al. · EClinicalMedicine · 0 citations