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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

M. Spalinger

h-index 32 View on Semantic Scholar

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Open access Sep 2026

T-Cell Specific Deletion of PTPN23 Alters T-Cell Development and TCRαβ/γδ Composition

Highlights What are the main findings? T-cell–specific deletion of PTPN23 causes a marked reduction in T-cells, accompanied by preferential accumulation of TCRγδ T-cells and enrichment of differentiated effector/memory T-cell subsets. Multi-omics and single-cell RNA sequencing reveal alterations in T-cell developmental...

Rocio Sanchez Alvarez, M. Determann, L. Linzmeier et al. · 0 citations
Open access Sep 2026

PTPN23 Overexpression Is Associated with Reduced Proliferation and Tumor Growth in Murine Models of Colorectal Cancer

In-vitro findings demonstrate that PTPN23 overexpression resulted in reduced proliferation levels and follow-up experiments showed suppression of colorectal cancer growth and proliferation in experimental CRC models, providing a basis for future studies addressing its biological function and therapeutic relevance.

Rocio Sanchez Alvarez, C. Gottier, A. Montalban-Arques et al. · 0 citations

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