M. Sturbaut

Fitness criteria for PROTACs as chemical probes: principles and applications.

Proteolysis-targeting chimeras (PROTACs) have emerged as a powerful class of chemical probes that degrade rather than inhibit target proteins, thus expanding the tools for studying protein function in cells. PROTACs trigger catalytic and sub-stoichiometric degradation of the target protein in contrast with stoichiometr...