The locus coeruleus (LC), the earliest site of tau accumulation in Alzheimer’s disease, directly influences pupillary and vergence oculomotor systems. Whether task-evoked oculomotor dynamics can non-invasively differentiate AT(N) profiles, A+T+ (biological Alzheimer’s disease) and A−T+ (suspected non-Alzheimer’s tauopa...
This study examined caregivers' preferences for digital content to support the care of individuals with dementia, particularly those with Alzheimer's disease (AD). An online survey was conducted with 147 caregivers affiliated with the Pasqual Maragall Foundation, assessing the perceived usefulness of content across...
D. Piromalli, Gloria Mas Vall-llosera, M. Ivirico et al.· Technology and Disability· 0 citations
INTRODUCTION: Biomarkers for monitoring disease activity and treatment response in peripheral neuropathies remain limited. Big tau, a high-molecular-weight isoform of tau, is predominantly expressed in the peripheral nervous system (PNS). We investigated serum levels of big tau, brain-derived tau (BD-tau), and neurofil...
L. Martín-Aguilar, F. González-Ortiz, H. Zetterberg et al.· medRxiv· 0 citations
Overall, current evidence on p-tau217 is derived mainly from selected populations and may not fully reflect real-world clinical diversity, so future studies should prioritize more representative cohorts and standardized reporting of key variables will be essential to strengthen its adoption in clinical practice.
M. T. Blasi, Simona Buscarnera, M. Salzillo et al.· Ageing Research Reviews· 0 citations
In this large longitudinal sample of asymptomatic individuals, the Aβ-dominant biomarker component showed the strongest association with longitudinal GM atrophy and cognitive decline, beyond the effects of tau pathophysiology and neuroaxonal injury.
W. Pelkmans, R. Cacciaglia, Michalis Kassinopoulos et al.· Molecular Neurodegeneration· 0 citations
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