M. T. Doyle

A diverse family of protein antibiotics inhibits the BAM complex by β-signal mimicry

Lectin-like protein antibiotics (Llps) kill Pseudomonas by inhibiting BamA, the essential core of the β-barrel assembly machinery (BAM). Llps are composed of one or two β-lectin domains and a C-terminal peptide, with characterisation to date centred on the two-domain L-type pyocins of P. aeruginosa, which bind BamA ext...