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M. Tansey

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Review Open access Jul 2026

Alzheimer's disease heterogeneity and co‐pathologies: Defining novel targets, biomarkers, modalities, and research methodologies

Key takeaways from the Fall 2025 AARR meeting are presented, which brought together academic, clinical, and industry leaders to discuss and explore the current advances in the heterogeneity and co‐pathologies of AD and their implications for diagnosis, clinical trial design, and precision treatment strategies.

M. Tansey, S. Bozeat, Peter Ackerman et al. · 0 citations
Review Open access Sep 2026

Inflammasomes: central mediators of neuroinflammatory neurodegeneration in Alzheimer’s and Parkinson’s disease

As life expectancy increases worldwide, the proportion of people aged 65 and older is expected to double by 2050 and these global demographic shifts will be accompanied by an increase in age-related neurodegenerative diseases such as Alzheimer’s (AD) and Parkinson’s disease (PD). AD is the leading cause of dementia w...

C. Tropis, Janna Jernigan Posey, M. Tansey et al. · 0 citations
Open access Jul 2026

LRRK2 G2019S reprograms innate and adaptive immunity to drive context-dependent host defense outcomes

Introduction Parkinson’s disease (PD) is increasingly recognized as a neurological disorder characterized not only by neurodegeneration but also by chronic immune dysregulation across the lifespan. Although the initiating events underlying PD remain unclear, accumulating evidence suggests that inflammatory processes ma...

Andrea R. Merchak, Mary K. Herrick, M. Houser et al. · 0 citations

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