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Open access Sep 2026

Advanced Intranasal Lipid-Based Nanocarrier System for Targeted Nose-to-Brain Delivery of Vortioxetine Hydrobromide: From Formulation to In vivo Pharmacokinetics

Objective: Vortioxetine HBr is a multimodal antidepressant with a very poor aqueous solubility (50 µg base/ml at pH 7.4) and an oral bioavailability of approximately 75% due to hepatic first-pass metabolism. Nose-to-brain drug delivery can bypass hepatic first-pass metabolism and achieve targeted drug therapy by circum...

Merhan Taha el-Nadi, Rehab Abdelmonem, M. el-Nabarawi et al. · 0 citations
Open access Aug 2026

Brain-targeted intranasal aripiprazole via modified chitosan nanoparticles: controlled release, pharmacokinetics, and pharmacodynamics.

Schizophrenia remains one of the most disabling mental disorders, and effective therapy is still limited by the difficulty of delivering drugs across the blood-brain barrier. Aripiprazole (Ari), a first-line atypical antipsychotic, exhibits restricted clinical performance due to poor solubility, extensive hepatic metab...

Rabab M Ibrahim, M. Teaima, M. el-Nabarawi et al. · 0 citations

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