Cathepsin B-Activated Vitamin E Prodrugs Target Cancer Stem Cells and Enhance Chemotherapy Response in Triple-Negative Breast Cancer with Minimal Cardiotoxicity.
Triple-negative breast cancer (TNBC) remains one of the most difficult malignancies to treat owing to high relapse, enrichment of cancer stem cells (CSCs), and constitutive activation of pro-survival signaling such as NF-κB. We conceived a new therapeutic concept-A Priori Activation of Apoptosis Pathways (AAAPT)-design...