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Author

M. Totsuka

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Open access Sep 2026

Imiquimod triggers TLR7-independent apoptosis but TLR7-dependent activation in murine CD4+ T cells.

Toll-like receptor 7 (TLR7) agonists are widely used as immunomodulatory agents, yet their direct effects on T cells remain incompletely understood. Here, we investigated the effects of imiquimod (IMQ) on purified murine CD4+ T cells using TLR7-deficient mice and pharmacological approaches. IMQ elicited both activating...

Ayako Aoki, M. Totsuka, M. Shimizu et al. · 0 citations

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