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M. Trimech

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Open access Sep 2026

Familial Pancreatic Cancer Associated with a Shared BRIP1 Variant: Implications for Homologous Recombination Deficiency and Targeted Therapy

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with a subset occurring in the context of hereditary cancer predisposition. BRIP1 is involved in homologous recombination repair, and pathogenic germline variants are established risk factors for ovarian cancer. However, its role in pa...

Nils Degrauwe, Giovanni Dei Tos, M. Trimech et al. · 0 citations

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