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Open access Sep 2026

Single-cell proteomics resolves major cell populations and protein-defined chondrocyte states in the adult human osteoarthritic joint

Objective Single-cell RNA sequencing has transformed our understanding of cellular heterogeneity within osteoarthritic (OA) joint tissues, yet transcript abundance provides only an indirect measure of cellular phenotype and function. Recent advances in mass spectrometry now enable proteins to be measured directly at si...

Leonie Müller, J. Mimpen, C. Todd et al. · 0 citations
Open access Aug 2026

Selective quality control of mistargeted mitochondrial proteins at the endoplasmic reticulum

It is shown that mitochondrial import stress drives widespread rerouting of mitochondrial proteins to the endoplasmic reticulum (ER), with strong enrichment for hydrophobic oxidative phosphorylation (OXPHOS) components.

Y. Tsuchiya, Nikita Sergejevs, M. E. Dueñas et al. · 0 citations

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