Blood pressure (BP) is a major, heritable determinant of cardiometabolic health. Genome-wide association studies (GWAS) have identified thousands of BP-influencing genetic variants. People of admixed American (AMR) ancestry harbour variants that are rare in other populations yet remain understudied in GWAS. Here, we pe...
M. Turner, J. Berumen, S. Morris et al.· medRxiv· 0 citations
Among AMR participants of the All of Us cohort, using MCPS-trained (vs. INTERVAL-trained) models to predict metabolomic traits yielded five times as many significant associations across three cardiometabolic diseases: ischaemic heart disease, type 2 diabetes, and chronic kidney disease.
T. Oreskovic, D. Jin, E. Trichia et al.· medRxiv· 0 citations
Elevated BP as a major modifiable risk factor for kidney failure mortality, CKD, and albuminuria is highlighted in this large prospective study in Mexican adults.
Doreen Zhu, P. Kuri-Morales, Rachel Wade et al.· American Journal of Kidney D...· 0 citations
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