Safety of Age-Adjusted and Clinical Probability-Adjusted D-dimer Cut-offs in Suspected Pulmonary Embolism: A Systematic Review and Meta-Analysis.
BACKGROUND Adaptive D-dimer strategies for rule out of pulmonary embolism (PE) have been proposed to improve the efficiency of conventional fixed '500' D-dimer thresholds. Validations of adaptive D-dimer strategies post-hoc in cohorts managed according to the fixed D-dimer threshold seems to questions their safety. Res...