Author

M. Waldor

3 papers indexed here

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Oct 2026

Tn7 Integration Efficiently Introduces Gene Expression Cassettes into a Gut-Native Escherichia coli Strain

Native bacteria are strains isolated from the host and often require greater development and optimization of genetic manipulation tools than lab-adapted strains. We have previously shown that the native murine Escherichia coli strain EcAZ-1, which colonizes the conventional mouse gut long term, is genetically tractab...

David M. Zong, Sharyl Bailey, Zainab Fatima et al. · ACS Synthetic Biology · 0 citations

Open access Sep 2026

Switching apo- and holo-IscR control of LcrF alters how iron and oxygen regulate Yersinia virulence factors

The lcrFpType1 mutant lcrFpType1 mutant experienced altered colonization bottleneck and dissemination patterns compared to WT Yersinia, suggesting that expressing LcrF and T3SS genes in response to [2Fe-2S]-IscR rather than apo-IscR may alter infection dynamics.

Mané Ohanyan, G. I. Balazs, Karthik Hullahalli et al. · Infection and Immunity · 0 citations

Open access Sep 2026

Dual roles of host N-glycosylation in enteropathogenic Escherichia coli infection.

Host factors determine pathogen tropism but knowledge of host genes facilitating enteropathogenic Escherichia coli (EPEC) infection is limited. To identify host determinants required for infection by EPEC, we performed two independent genome-scale CRISPR-Cas9 screens. Both converged on host N-glycosylation as a critica...

Klil Cohen-Yaron, Yaakov Socol, Noam Yedidi et al. · Cell Reports · 0 citations