Author

M. Walker

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Sep 2026

EFTUD2-Regulated Alternative Splicing of MSH5 Drives Radioresistance in Recurrent IDH-Mutant Glioma.

BACKGROUND Recurrent IDH-mutant gliomas frequently acquire increased radioresistance, leading to poorer outcomes. Their underlying mechanisms, however, remain largely unknown. We hypothesize that dysregulated RNA alternative splicing (AS) during IDH-mutant glioma recurrence contributes to the enhanced radioresistance b...

Qiu He, Run-Xin Wu, Xiao-Zhou Yu et al. · Neuro-Oncology · 0 citations

Open access Jul 2026

iPSC-Derived Microglia-like Cells Exhibit Protocol-Dependent Transcriptomic Features and Robust Phagocytosis of Glioma Cells

Microglia are the brain-resident macrophages and key regulators of the brain tumor microenvironment. Although induced pluripotent stem cell-derived microglia (iMG) provide a valuable model for studying human microglial, systematic comparisons of differentiation protocols are limited, and their utility for modeling micr...

M. Walker, Hui Tang, Caylee Silvers et al. · bioRxiv · 0 citations