M. Winokan

A resource-efficient structure-based workflow for fragment progression enables parallel hit discovery and validation of functionally diverse modulators of NCS-1 protein–protein interactions

Efficient drug discovery workflows ideally generate data that directly address key translational milestones, including confirmation of target engagement and binding pose, structure–activity relationships (SARs), and biological relevance, within rapid and resource-efficient experimental cycles. Here, we describe a data-...