Hyperphosphorylated tau pathology in patients with epilepsy and dementia - Neuropathological insights from a historical autopsy cohort.
OBJECTIVE Accumulation of hyperphosphorylated tau (pTau) is a proposed mechanism for dementia associated with epileptic seizures but the evidence directly linking seizures and pTau accumulation remains weak. Here, we aimed at determining the burden of pTau pathology in a historical cohort of epilepsy patients who devel...