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Author

M. Wittling

2 papers indexed here

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Open access Oct 2026

Neoadjuvant pepinemab in combination with nivolumab and/or ipilimumab in resectable metastatic melanoma: a pilot biomarker-driven trial

Neoadjuvant immune checkpoint inhibitors (ICIs) improve event-free survival in metastatic melanoma, yet resistance and recurrence remain common. Here we evaluated pepinemab, a Semaphorin 4D (SEMA4D)–blocking antibody, in combination with anti-PD1 nivolumab and/or anti-CTLA4 ipilimumab in a pilot biomarker-driven neoa...

A. Ruffin, C. Mallow, B. Olson et al. · 0 citations
Sep 2026

Abstract B086: Mesothelin-targeted CAR Th1/17 cells are a novel cellular engineering platform for pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) remains refractory to immunotherapies, including adoptive T cell therapy, necessitating evaluation of alternative T cell engineering platforms in immunosuppressive solid tumors. Human CD4+ T cells co-secreting IFN-γ and IL-17A (Th1/17 hybrids) have demonstrated enhanced ant...

Delaney K. Geitgey, Megan M. Wyatt, Maggie J. Phillips et al. · 0 citations

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