The CACNA1C gene encodes the α1C subunit of voltage-gated CaV1.2 calcium channels, serving many pivotal functions throughout the body, including in the heart and brain. Clinical and genetic evidence implicates altered expression and/or function of CACNA1C/CaV1.2 in both cardiac and neuropsychiatric disease, including h...
David Königstein, Theresa M. Kisko, Susanne Michels et al.· Biomolecules· 0 citations
Serotonin (5-HT) regulates neurodevelopment and behavior. Whereas central 5-HT is synthesized by tryptophan hydroxylase (TPH)-2, the TPH1 isoform produces 5-HT peripherally. Although these systems are anatomically segregated, TPH1 gene polymorphisms have been linked to neuropsychiatric vulnerability, suggesting that pe...
Rogério C. R. Castro, N. Alenina, E. E. Natasha et al.· Brain, behavior, and immunit...· 0 citations
It is demonstrated that 5-HT depletion disrupts behavioral neurodevelopmental trajectories via interactions between genetic, environmental, and ecological factors, highlighting the importance of accounting for sex, environment, and developmental timing in translational research.
Marta C. F. Samina, Rogério C. R. Castro, Thijs Lodder et al.· Translational Psychiatry· 0 citations
It is demonstrated that GluD1 is indispensable for preserving GluN2B-containing NMDAR function, synaptic plasticity, and memory, providing molecular insight into how GluD1 regulates NMDAR subtypes implicated in synaptic dysfunction in neuropsychiatric disorders.
Eric Purisic, Darielle Lewis-Sanders, Marian Zhong et al.· bioRxiv· 0 citations
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