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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

M. Wyss

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Open access Oct 2025

Multiplexed embryo profiling links cellular state to zygotic genome activation in single cells

Multicellular self-organization relies on complex interactions across multiple length scales, shaping the transcriptional activity and molecular phenotype of individual cells. Despite advances in spatial omics technologies, mapping protein state composition at high spatial resolution to capture the molecular phenotype...

Max Hess, M. Wyss, Edlyn Wu et al. · 3 citations
Open access Oct 2026

3D Iterative Immunofluorescence Imaging on Whole-Mount Samples

Multicellular organization relies on reciprocal interactions between molecular events, such as gene expression and protein state, and higher-scale properties, such as spatial patterning and tissue architecture. Understanding these processes requires methods that enable quantitative measurements at subcellular resolutio...

M. Wyss, Max Hess, Shayan Shamipour et al. · 0 citations
Open access Sep 2026

Multiplexed embryo profiling links cellular state to zygotic genome activation in single cells

The cell cycle phase is the major source of variability in transcription within a division cycle, and combining this with the analysis of key transcription factors and chromatin modifier state enables accurate prediction of transcriptional output during zygotic genome activation in individual cells.

Max Hess, M. Wyss, Edlyn Wu et al. · 0 citations

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