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TYK2 and NOTCH4 variants are markedly associated with increased COVID-19 severity and mortality, indicating their potential as genetic biomarkers for risk stratification and support the importance of host genetics in disease progression.
RIOK3 is identified as a promising therapeutic target for PDAC, with Venetoclax, Conivaptan, Drospirenone, and Irinotecan as repurposable candidates for further research.
The findings suggest no significant association between the HTR2A rs6313 and ASD susceptibility in the Jordanian population, and emphasize the need for larger, multi-marker studies to account for regional genetic diversity.
There is a lack of association between the CYP4F2 rs2108622 genotype and valsartan and amlodipine responses among a sample of Jordanians with essential hypertension, and the absence of statistical significance supports the need for larger pharmacogenetic studies.
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