Author

Madeline Collins

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Open access Aug 2026

Disruption of the interferon-gamma axis limits chimeric antigen receptor T cell efficacy against acute myeloid leukemia

It is demonstrated that disruption of the IFNγ axis impedes anti-AML CAR T cell function and prevents upregulation of target antigen CD123, the apoptotic mediator Fas, and the adhesion molecule ICAM-1 on AML cells.

Nat Murren, Isaac King, Lauren Mahoney et al. · bioRxiv · 0 citations