Madeline Fitzgibbon

Abstract B119: Generation of an Endogenous PDAC-Specific TCR Transgenic Mouse

Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest malignancies and remains largely refractory to chemotherapy and immunotherapy. Although KRAS inhibitors show promising initial efficacy, resistance rapidly emerges, and immunotherapy responses are mostly restricted to the rare subset of patients with micr...