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Madeline Labott

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Open access Oct 2026

Disease-associated mutations directionally modulate epigenetic age in iPSC-derived tissues

Reprogramming somatic cells into induced pluripotent stem cells (iPSCs) resets epigenetic age, creating a major challenge for modeling age-associated cellular states and limiting the use of iPSCs in aging research beyond the genetic component. Recent work has shown that healthy organoids can re-accumulate age-associate...

Nicholas J. Skvir, Todd W. Dowrey, Samuel F. Cranston et al. · 0 citations

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