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Madhav Mantri

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Open access Aug 2026

A NON-CANONICAL ROLE FOR NOTCH3 IN BUILDING THE INTESTINAL LYMPHATIC NICHE

Lymphatic dysfunction drives severe and often intractable human diseases, yet the cellular mechanisms that establish functional lymphatic vasculature remain poorly understood. In the intestine, lacteals are specialized lymphatic vessels that absorb dietary lipids and rely on surrounding villus smooth muscle to propel l...

Li-Qing Huang, Bhargav D. Sanketi, Madhav Mantri et al. · 0 citations
Open access Aug 2026

High-resolution spatial transcriptomics maps viral tropism and reveals spatially organized immune modules in viral encephalitis

Viral encephalitis is a debilitating disease that most commonly affects vulnerable populations, including the very young and elderly. Despite its severity, few countermeasures exist due to the structural and immunological complexities of the central nervous system (CNS). To better understand the spatial dynamics of vir...

Chase Holdener, Shao-Wen Jiang, Kira A. Griswold et al. · 0 citations
Open access Sep 2026

Single-cell splice isoform usage reveals distinct axes of cellular identity and senescence

A cross-tissue single-cell long-read isoform atlas spanning 26 human tissues is presented and it is demonstrated that isoform usage is a structured, measurable axis of cellular identity that is distinct from gene expression.

Madhav Mantri, A. Detweiler, Jaeyoon Lee et al. · 0 citations

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